High Point University baseball coach Joey Hammond has announced the spring 2022 schedule.
 
The 2022 schedule features matchups with 2021 NCAA College World Series Semifinalist North Carolina State, as well as NCAA Regional participants Northeastern, Presbyterian College, Duke, Jacksonville, Campbell, and Liberty. The Panthers are also set to meet other Power 5 members Virginia Tech, Pitt, West Virginia, and Wake Forest.
 
The first pitch of the season will take place in Jacksonville, Florida, against Jacksonville University on February 18. The Panthers will open the season at Williard Stadium on February 25 against Toledo in the first home series of 2022.